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Article

Recombinase-based conditional and reversible gene regulation via XTR alleles.

Nature communications - 5 Nov 2015

Robles-Oteiza Camila, Taylor Sarah, Yates Travis, Cicchini Michelle, Lauderback Brian, Cashman Christopher R, Burds Aurora A, Winslow Monte M, Jacks Tyler, Feldser David M

Abstract excerpt

Synthetic biological tools that enable precise regulation of gene function within in vivo systems have enormous potential to discern gene function in diverse physiological settings. Here we report the development and characterization of a synthetic gene switch that, when targeted in the mouse germline, enables conditional inactivation, reports gene expression and allows inducible restoration of the targeted gene....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26537451
DOI: 10.1038/ncomms9783
PMCID: PMC4635517

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