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Article

Cell-Type-Specific Gene Inactivation and In Situ Restoration via Recombinase-Based Flipping of Targeted Genomic Region.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Sept 2020

Liu Xue, Ma Liang, Liu Hongzhi, Gan Jingwen, Xu Yidan, Zhang Tianrui, Mu Peiyuan, Wu Jinyun, Shi Yun, Zhang Yubin, Gong Ling, He Miao

Abstract excerpt

Conditional gene inactivation and restoration are powerful tools for studying gene functions in the nervous system and for modeling neuropsychiatric diseases. The combination of the two is necessary to interrogate specific cell types within defined developmental stages. However, very few methods and animal models have been developed for such purpose. Here we present a versatile method for conditional gene...

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Identifiers

PMID: 32801153
DOI: 10.1523/JNEUROSCI.1044-20.2020
PMCID: PMC7480235

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