Article

Proinsulin C-peptide is a major source of HLA-DQ8 restricted HIPs recognized by human Islet-Infiltrating CD4 <sup>+</sup> T cells

2024-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D) is an autoimmune disease that develops when T cells destroy the pancreatic insulin-producing beta cells that reside in the pancreatic islets. Immune cells, including T cells infiltrate the islets and gradually destroy the beta cells. Human islet-infiltrating CD4 + T cells recognize peptide epitopes derived from proinsulin, particularly C-peptide. Hybrid Insulin peptides (H...

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Literature Corpus work: 65cbc605-5c8f-5a67-8c2a-6747bca325f2
DOI: 10.1101/2024.05.09.593303

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