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Human islet T cells are highly reactive to preproinsulin in type 1 diabetes

5 Oct 2021

Abstract excerpt

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are major self-antigens targeted by T cells. We comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without T1D and identified epitopes throughout the entire preproinsulin...

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PMID: 34611019
DOI: 10.1073/pnas.2107208118

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