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Article

Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors

25 Mar 2021

Abstract excerpt

Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific immunotherapies for type 1 diabetes (T1D). In this study, we sought to comprehensively evaluate reactivity to preproinsulin by CD4 T cells originally isolated from pancreatic islets of organ donors having T1D. We analyzed 187 T cell receptor (TCR) clonotypes expressed...

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PMID: 33841327
DOI: 10.3389/fendo.2021.622647

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