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The Regulation and Immune Signature of Retrotransposons in Cancer

30 Aug 2023

Abstract excerpt

Advances in sequencing technologies and the bioinformatic analysis of big data facilitate the study of jumping genes' activity in the human genome in cancer from a broad perspective. Retrotransposons, which move from one genomic site to another by a copy-and-paste mechanism, are regulated by various molecular pathways that may be disrupted during tumorigenesis. Active retrotransposons can stimulate type I IFN...

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PMID: 37686616
DOI: 10.3390/cancers15174340

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