Article

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

2023-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Overexpression of repetitive elements is an emerging hallmark of human cancers 1 . Diverse repeats can mimic viruses by replicating within the cancer genome through retrotransposition, or presenting pathogen-associated molecular patterns (PAMPs) to the pattern recognition receptors (PRRs) of the innate immune system 2–5 . Yet, how specific repeats affect tumor evolution and shape the tumor imm...

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Literature Corpus work: ac8b0089-b74d-5d3b-b382-855c18d92753
DOI: 10.1101/2023.05.19.541456

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