Article

Comprehensive characterization of LINE-1 antisense promoter-driven genes across human cancers

2023-04-18

Abstract excerpt

<h4>Background: </h4> Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human genome. As the only autonomous and active retrotransposon, L1 plays an essential role in cancer initiation and progression. The studies of L1 in cancer mainly focus on the impact of L1 insertion into the new genome locus. The L1 5´ untranslated region (UTR) also contains antisense promoter (ASP) activity, generating...

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Literature Corpus work: 9f7ff30f-1fc9-5885-99d1-254008b3ec02
DOI: 10.21203/rs.3.rs-2799071/v1

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