Article

The type 1 diabetes gene <i>TYK2</i> regulates β-cell development and its responses to interferon-α

2022-02-22

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN) mediated intracellular signaling. To study the role of TYK2 in human pancreatic β-cell development and response to IFNα, we generated TYK2 knockout human iPSCs and directed...

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Literature Corpus work: 656de701-6f47-5ee0-be01-5ca3084c6c52
DOI: 10.1101/2022.02.22.481272

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