Article

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance

2021-02-25

Abstract excerpt

<title>Abstract</title> <p>Naturally occurring cases of monogenic type 1 diabetes (T1D) provide rare opportunities to establish direct mechanisms that cause this complex autoimmune disease. A recently identified de novo germline gain-of-function (GOF) mutation in the transcriptional regulator signal transducer and activator of transcription 3 (STAT3) was shown to cause neonatal T1D at birth. To investigate the ro...

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Literature Corpus work: f1b72d5f-ac76-55da-9f6f-ec272e33164c
DOI: 10.21203/rs.3.rs-257641/v1

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