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TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.

Genes - 11 Mar 2021

Mori Hitoe, Takahashi Hirokazu, Mine Keiichiro, Higashimoto Ken, Inoue Kanako, Kojima Motoyasu, Kuroki Shigetaka, Eguchi Takahisa, Ono Yasuhiro, Inuzuka Sadataka, Soejima Hidenobu, Nagafuchi Seiho, Anzai Keizo

Abstract excerpt

Accumulating evidence has suggested that viral infection causes type 1 diabetes due to direct β-cell damage and the triggering of autoimmune reactivity to β cells. Here, we elucidated that the tyrosine kinase 2 (Tyk2) gene, encoding an interferon receptor signaling molecule, is responsible for virus-induced diabetes in mice, and its promoter variant confers a risk of type 1 diabetes in humans. This study...

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Share to Body Mass Index
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin Resistance

Share to Insulin Secretion

Share to Promoter Regions, Genetic

Share to Sulfonylurea Compounds

Share to TYK2 Kinase

Source

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Identifiers

PMID: 33799705
DOI: 10.3390/genes12030400
PMCID: PMC7999758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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