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The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

26 Oct 2022

Abstract excerpt

Abstract Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2 , which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of TYK2 in β-cell development and response to IFNα, we generated TYK2 knockout human iPSCs and directed them...

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PMID: 36289205
DOI: 10.1038/s41467-022-34069-z

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