Article

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

2024-03-23

Abstract excerpt

<h4>SUMMARY</h4> Tyrosine protein-kinase 2 (TYK2), a member of the Janus kinase family, mediates inflammatory signaling through multiple cytokines, including interferon-α (IFNα), interleukin (IL)-12, and IL-23. Missense mutations in TYK2 are associated with protection against type 1 diabetes (T1D), and inhibition of TYK2 shows promise in the management of other autoimmune conditions. Here, we evaluated the effect...

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Literature Corpus work: 2c94fdcb-4a48-5169-8f42-65e7f717c7ea
DOI: 10.1101/2024.03.20.585925

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