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TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.

Diabetes - 1 Nov 2015

Marroqui Laura, Dos Santos Reinaldo Sousa, Fløyel Tina, Grieco Fabio A, Santin Izortze, Op de Beeck Anne, Marselli Lorella, Marchetti Piero, Pociot Flemming, Eizirik Decio L

Abstract excerpt

Pancreatic β-cells are destroyed by an autoimmune attack in type 1 diabetes. Linkage and genome-wide association studies point to >50 loci that are associated with the disease in the human genome. Pathway analysis of candidate genes expressed in human islets identified a central role for interferon (IFN)-regulated pathways and tyrosine kinase 2 (TYK2). Polymorphisms in the TYK2 gene predicted to decrease function...

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Share to Cell Survival
Share to Chemokine CXCL10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genes, MHC Class I

Share to Immunity, Innate

Share to Insulin-Secreting Cells

Share to Interferon-alpha

Share to TYK2 Kinase

Source

Identifiers

PMID: 26239055
DOI: 10.2337/db15-0362

Genes

TYK2
CXCL10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.PMID 26239055Read ↗

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-αSemantic proximity Read ↗

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceSemantic proximity Read ↗

The type 1 diabetes gene <i>TYK2</i> regulates β-cell development and its responses to interferon-αSemantic proximity Read ↗

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.Semantic proximity Read ↗

TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.Semantic proximity Read ↗

The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus.Semantic proximity Read ↗

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and <i>β</i> ‐cell apoptosisSemantic proximity Read ↗

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.Semantic proximity Read ↗

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