Article

Somatic <i>TYK2</i> activating mutations in tumor-infiltrating T cells promote anti-cancer immunity

2025-10-15

Abstract excerpt

Cancer cells evolve to increase fitness and evade the immune system, but it is not clear if tumor infiltrating lymphocytes (TILs) undergo selection for somatic mutations that augment anti-cancer immunity. Using single molecule whole exome sequencing in TILs, we identified somatic mutations in Tyrosine-protein kinase 2 ( TYK2 ), several of which increased TYK2 phosphorylation, JAK-STAT signaling, and interferon ga...

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Identifiers and source

Literature Corpus work: ee13ccc0-395f-5158-8fde-a4ae876f65cb
DOI: 10.1101/2025.10.13.682217

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