Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.

doi:10.1038/ncomms7748

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Article

Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.

Nature communications - 7 Apr 2015

Izumi Kenichi, Mine Keiichiro, Inoue Yoshitaka, Teshima Miho, Ogawa Shuichiro, Kai Yuji, Kurafuji Toshinobu, Hirakawa Kanako, Miyakawa Daiki, Ikeda Haruka, Inada Akari, Hara Manami, Yamada Hisakata, Akashi Koichi, Niho Yoshiyuki, Ina Keisuke, Kobayashi Takashi, Yoshikai Yasunobu, Anzai Keizo, Yamashita Teruo, Minagawa Hiroko, Fujimoto Shuji, Kurisaki Hironori, Shimoda Kazuya, Katsuta Hitoshi, Nagafuchi Seiho

Abstract excerpt

Accumulating evidence suggests that viruses play an important role in the development of diabetes. Although the diabetogenic encephalomyocarditis strain D virus induces diabetes in restricted lines of inbred mice, the susceptibility genes to virus-induced diabetes have not been identified. We report here that novel Tyrosine kinase 2 (Tyk2) gene mutations are present in virus-induced diabetes-sensitive SJL and SWR...

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Identifiers

PMID: 25849081
DOI: 10.1038/ncomms7748
PMCID: PMC4396380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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