Article

Clustering of colon, lung, and other cancer susceptibility genes with protein tyrosine phosphatases and protein kinases in multiple short genomic regions

2023-11-10

Abstract excerpt

Interactions of large gene families are poorly understood. We found that human, mouse, and rat colon and lung cancer susceptibility genes, presently considered as separate gene families, were frequently pairwise linked. The orthologous mouse map positions of 142 of 159 early discovered colon and lung cancer susceptibility genes formed 41 genomic clusters conserved >70 million years. These linked gene pairs concord...

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Literature Corpus work: 6518efe4-bdb9-5ea3-bd4c-630111c5cc9c
DOI: 10.1101/2023.11.07.566108

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