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Article

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

5 Jul 2007

Abstract excerpt

BACKGROUND: The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared gene expression patterns of human colorectal cancers (CRCs) and mouse colon tumor models to those of mouse colon development embryonic days 13.5-18.5....

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PMID: 17615082
DOI: 10.1186/gb-2007-8-7-r131

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