Article

Evolutionarily conserved clusters of colon with lung cancer susceptibility loci, linked with most DUSP phosphatase genes, may help to dissect mechanisms of cancer susceptibility

2021-10-14

Abstract excerpt

We show evolutionarily conserved pairwise genetic linkage and clustering of majority of colon and lung cancer susceptibility QTLs in mice, rats and humans. The patterns of susceptibility or resistance to these two cancers in recombinant congenic mouse strains were concordant and the responsible susceptibility loci closely linked, in spite of completely different carcinogens and protocols used for induction of the...

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Literature Corpus work: 28a01b7c-7250-5994-bab3-de0b929cd51a
DOI: 10.1101/2021.10.13.461047

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