Article
Use of genome-wide association studies for cancer research and drug repositioning.
PloS one - 1 Jan 2015
Zhang Jizhun, Jiang Kewei, Lv Liang, Wang Hui, Shen Zhanlong, Gao Zhidong, Wang Bo, Yang Yang, Ye Yingjiang, Wang Shan
Abstract excerpt
Although genome-wide association studies have identified many risk loci associated with colorectal cancer, the molecular basis of these associations are still unclear. We aimed to infer biological insights and highlight candidate genes of interest within GWAS risk loci. We used an in silico pipeline based on functional annotation, quantitative trait loci mapping of cis-acting gene, PubMed text-mining,...
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