Integrative Principal Component-QTL Mapping Identifies Genetic Modifiers of Tumor and Metabolic Traits in Smad4-Deficient Collaborative Cross Mice.

doi:10.3390/ijms27167254

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Integrative Principal Component-QTL Mapping Identifies Genetic Modifiers of Tumor and Metabolic Traits in Smad4-Deficient Collaborative Cross Mice.

International journal of molecular sciences - 14 Aug 2026

Zohud Osayd, Midlej Kreem, Iraqi Fuad A

Abstract excerpt

Genetic background strongly influences the penetrance and phenotypic expression of SMAD4-associated intestinal tumorigenesis, yet the underlying modifier loci remain poorly defined. To investigate the genetic architecture of tumor susceptibility and systemic physiology, we analyzed 260 Smad4+/- × Collaborative Cross (CC)-F1 mice derived from 14 CC lines using 11 quantitative traits, including longitudinal body...

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Chromosome Mapping
Genes, Modifier
Genetic Predisposition to Disease
Intestinal Neoplasms
Mice
Principal Component Analysis

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Quantitative Trait Loci

Smad4 Protein

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Open in PubMed Open full text

Identifiers

PMID: 42653258
DOI: 10.3390/ijms27167254
PMCID: PMC13512919

Genes

CAST
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.