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Article

Systems genetics analysis of cancer susceptibility: from mouse models to humans.

Nature reviews. Genetics - 1 Sept 2009

Quigley David, Balmain Allan

Abstract excerpt

Genetic studies of cancer susceptibility have shown that most heritable risk cannot be explained by the main effects of common alleles. This may be due to unknown gene-gene or gene-environment interactions and the complex roles of many genes at different stages of cancer. Studies using mouse models of cancer suggest that methods that integrate genetic analysis and genomic networks with knowledge of cancer biology...

Topics

Animals
Disease Models, Animal
Gene Regulatory Networks
Genetic Predisposition to Disease
Humans
Mice
Models, Biological
Neoplasms
Quantitative Trait Loci
Systems Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19636343
DOI: 10.1038/nrg2617

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