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Article

Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats.

PloS one - 24 Feb 2011

Quan Lei, Stassen Alphons P M, Ruivenkamp Claudia A L, van Wezel Tom, Fijneman Remond J A, Hutson Alan, Kakarlapudi Neelima, Hart Augustinus A M, Demant Peter

Abstract excerpt

Genetic predisposition controlled by susceptibility quantitative trait loci (QTLs) contributes to a large proportion of common cancers. Studies of genetics of cancer susceptibility, however, did not address systematically the relationship between susceptibility to cancers in different organs. We present five sets of data on genetic architecture of colon and lung cancer susceptibility in mice, humans and rats....

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PMID: 21390212
DOI: 10.1371/journal.pone.0014727
PMCID: PMC3044722

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