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Article

Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron

1 Sept 2023

Abstract excerpt

The pairing of antibody genes IGHV2-5/IGLV2-14 is established as a public immune response that potently cross-neutralizes SARS-CoV-2 variants, including Omicron, by targeting class-3/RBD-5 epitopes in the receptor binding domain (RBD). LY-CoV1404 (bebtelovimab) exemplifies this, displaying exceptional potency against Omicron sub-variants up to BA.5. Here, we report a human antibody, 002-S21B10, encoded by the...

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PMID: 37708028
DOI: 10.1016/j.celrep.2023.113150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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