Article

Structural determinants of IGHV1-69 public antibodies conferring resilience to SARS-CoV-2 antigenic escape

2025-12-22

Abstract excerpt

R1-32-like public antibodies, characterized by shared IGHV1-69/IGLV1-40 usage, are elicited in more than 50% of individuals with COVID-19 and have been implicated in driving recurrent mutations at L452 SARS2 and F490 SARS2 within their convergent epitope in the SARS-CoV-2 spike receptor-binding domain. These mutations effectively mediate escape from non-affinity-matured R1-32-like antibodies with germline-like s...

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Literature Corpus work: 55cfef46-69e1-5565-9ecb-894775f0df69
DOI: 10.64898/2025.12.19.695307

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