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Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

28 Sept 2021

Abstract excerpt

Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody, 910-30, targeting the SARS-CoV-2 receptor-binding site for ACE2 as a member of a public antibody response encoded by IGHV3-53/IGHV3-66 genes. Sequence and structural analyses of 910-30 and related antibodies explore how class recognition features correlate...

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PMID: 34587480
DOI: 10.1016/j.celrep.2021.109771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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