Article

Somatic evolution of a cross-reactive germline antibody that expands its breadth to neutralize new SARS-CoV-2 variants

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Rapid antigenic drift of the SARS-CoV-2 receptor-binding domain (RBD) underlies immune escape and continues to challenge the durability of antibody-mediated protection. Among the major classes of RBD-directed antibodies, germline-encoded IGHV3-53 responses are highly potent against early SARS-CoV-2 variants but are generally compromised by Omicron-associated mutations. Here, we identify an intr...

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Literature Corpus work: 67f146fd-d296-50f3-b47e-765af6f09686
DOI: 10.64898/2026.03.20.713312

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