Article

Dissecting the impact of somatic hypermutation on SARS-CoV-2 neutralization and viral escape

2023-05-09

Abstract excerpt

<h4>SUMMARY</h4> Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-CoV-2 neutralizing antibodies. Yet, several potent SARS-CoV-2 antibodies carry no or only few mutations, leaving the question of how ongoing SHM affects neutralization. Here, we reverted variable region mutations of 92 antibodies and tested their impact on SARS-CoV-2 binding and neutralization. Reverting high...

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Literature Corpus work: 6ad350cb-387f-5469-8b8f-e3a39f6a051d
DOI: 10.1101/2023.05.09.539943

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