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CD3e-immunotoxin spares CD62L <sup>lo</sup> Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e <sup>hi</sup> T cells

2022-07-25

Abstract excerpt

CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy for largely unknown reasons. Tissue-resident T cells that persist in peripheral tissues have been shown to play pivotal roles in local and systemic immunity, as well as transplant rejection, autoimmunity and cancers. The impact of CD3e-I...

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Literature Corpus work
64f13c8b-e4cc-5f47-869b-24f6bedc09fb
DOI
10.1101/2022.07.25.501205
Open publication

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CD3e-immunotoxin spares CD62L <sup>lo</sup> Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e <sup>hi</sup> T cellsDOI 10.1101/2022.07.25.501205
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