Article
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands.
GeroScience - 1 Aug 2022
Trujillo-Vargas Claudia M, Mauk Kelsey E, Hernandez Humberto, de Souza Rodrigo G, Yu Zhiyuan, Galletti Jeremias G, Dietrich Jana, Paulsen Friedrich, de Paiva Cintia S
Abstract excerpt
Aging is associated with a massive infiltration of T lymphocytes in the lacrimal gland. Here, we aimed to characterize the immune phenotype of aged CD4+ T cells in this tissue as compared with lymphoid organs. To perform this, we sorted regulatory T cells (Tregs, CD4+CD25+GITR+) and non-Tregs (CD4+CD25negGITRneg) in lymphoid organs from female C57BL/6J mice and subjected these cells to an immunology NanoString®...
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