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Identification of a Highly Functional Effector CD8 <sup>+</sup> T Cell Program after Transplantation in Mice and Humans

2024-12-02

Abstract excerpt

<h4>ABSTRACT</h4> T cell mediated allograft rejection leads to early graft loss for kidney transplant patients. To better understand the mechanism by which T cells mediate rejection, we investigated the fate and function of graft-specific CD8 + T cells expressing the activated isoform of CD43 in mice and humans. Agonism of CD43 1B11 in vitro induced CD8 + T cell proliferation in the presence of sub-threshold an...

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Literature Corpus work
7640d2ee-9dce-58b5-a2fa-9a17e9e31ef7
DOI
10.1101/2024.11.26.625263
Open publication

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Identification of a Highly Functional Effector CD8 <sup>+</sup> T Cell Program after Transplantation in Mice and HumansDOI 10.1101/2024.11.26.625263
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