Article

Hiding in Plain Sight: CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues

2023-12-24

Abstract excerpt

For decades, regulatory T cell (Treg) research has focussed on CD4+FOXP3+ Tregs, while characterisation of CD8+FOXP3+ Tregs has been limited due to their scarcity in blood. Here, by analysing 95 tissue samples from 26 deceased transplant organ donors we show that, despite representing less than 5% of circulating Tregs, CD8+ Tregs are enriched in human tissue, particularly in non-lymphoid tissues and bone marrow. W...

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Literature Corpus work: 9971278b-a96a-528f-83ff-111d8e0e3c6c
DOI: 10.1101/2023.12.24.573232

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