Article
Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation.
Transplantation - 1 Oct 2017
Lam Avery J, Hoeppli Romy E, Levings Megan K
Abstract excerpt
Cellular therapy with CD4FOXP3 T regulatory (Treg) cells is a promising strategy to induce tolerance after solid-organ transplantation or prevent graft-versus-host disease after transfer of hematopoietic stem cells. Treg cells currently used in clinical trials are either polyclonal, donor- or antigen-specific. Aside from variations in isolation and expansion protocols, however, most therapeutic Treg cell-based...
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