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Article

Varying virulence: epigenetic control of expression noise and disease processes.

Trends in biotechnology - 1 Oct 2011

Miller-Jensen Kathryn, Dey Siddharth S, Schaffer David V, Arkin Adam P

Abstract excerpt

Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest that intrinsic noise arises from transcriptional bursts caused by slow, random transitions...

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PMID: 21700350
DOI: 10.1016/j.tibtech.2011.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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