Article
Varying virulence: epigenetic control of expression noise and disease processes.
Trends in biotechnology - 1 Oct 2011
Miller-Jensen Kathryn, Dey Siddharth S, Schaffer David V, Arkin Adam P
Abstract excerpt
Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest that intrinsic noise arises from transcriptional bursts caused by slow, random transitions...
Topics
- Animals
- Chromatin Assembly and Disassembly
- Computational Biology
- Epigenesis, Genetic
- Gene Expression Regulation
- Humans
- Neoplasms
- Phenotype
- Transcription, Genetic
- Virus Latency