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Article

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.

Molecular cell - 4 Aug 2006

Wang Xin, Zou Lee, Lu Tao, Bao Shilai, Hurov Kristen E, Hittelman Walter N, Elledge Stephen J, Li Lei

Abstract excerpt

The ATR-mediated checkpoint is not only critical for responding to genotoxic stress but also essential for cell proliferation. The RFC-related checkpoint protein Rad17, a phosphorylation substrate of ATR, is critical for ATR-mediated checkpoint signaling and cell survival. Here, we show that phosphorylation of Rad17 by ATR is important for genomic stability and restraint of S phase but is not essential for cell...

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Identifiers

PMID: 16885023
DOI: 10.1016/j.molcel.2006.06.022

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.PMID 16885023Read ↗

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