Article
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.
Oncogene - 8 Nov 2001
Koniaras K, Cuddihy A R, Christopoulos H, Hogg A, O'Connell M J
Abstract excerpt
Cell cycle checkpoints are surveillance mechanisms that monitor and coordinate the order and fidelity of cell cycle events. When defects in the division program of a cell are detected, checkpoints prevent the pursuant cell cycle transition through regulation of the relevant cyclin-cdk complex(es). Checkpoints that respond to DNA damage have been described for the G1, S and G2 phases of the cell cycle. The p53...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.