Article

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

2024-12-07

Abstract excerpt

Lenacapavir (LEN) is a highly potent, long-acting antiretroviral medication for treating people infected with muti-drug-resistant HIV-1 phenotypes. The inhibitor targets multifaceted functions of the viral capsid protein (CA) during HIV-1 replication. Previous studies have mainly focused on elucidating LEN’s mode of action during viral ingress. Additionally, the inhibitor has been shown to interfere with mature ca...

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Literature Corpus work: 64acb508-6fa4-5f79-af32-f8e5d0a0284c
DOI: 10.1101/2024.12.06.627250

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