Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.

Journal of virology - 1 Feb 2011

Keller Paul W, Adamson Catherine S, Heymann J Bernard, Freed Eric O, Steven Alasdair C

Abstract excerpt

Maturation of nascent virions, a key step in retroviral replication, involves cleavage of the Gag polyprotein by the viral protease into its matrix (MA), capsid (CA), and nucleocapsid (NC) components and their subsequent reorganization. Bevirimat (BVM) defines a new class of antiviral drugs termed maturation inhibitors. BVM acts by blocking the final cleavage event in Gag processing, the separation of CA from its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, gag

Share to HeLa Cells

Share to Succinates

Share to Triterpenes

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 21106735
DOI: 10.1128/JVI.01926-10
PMCID: PMC3028903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.PMID 21106735Read ↗

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation.Semantic proximity Read ↗

A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.Semantic proximity Read ↗

Preservation of HIV-1 Gag Helical Bundle Symmetry by Bevirimat Is Central to Maturation Inhibition.Semantic proximity Read ↗

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavirSemantic proximity Read ↗

High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation.Semantic proximity Read ↗

Maturation inhibitors facilitate virus assembly and release of HIV-1 capsid P224 mutant.Semantic proximity Read ↗

The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation.Semantic proximity Read ↗

PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.Semantic proximity Read ↗

The choreography of HIV-1 proteolytic processing and virion assembly.Semantic proximity Read ↗

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in MaturationSemantic proximity Read ↗

HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus MaturationSemantic proximity Read ↗

Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.