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Pharmacological intervention of HIV-1 maturation

13 Jun 2015

Abstract excerpt

Despite significant advances in antiretroviral therapy, increasing drug resistance and toxicities observed among many of the current approved human immunodeficiency virus (HIV) drugs indicate a need for discovery and development of potent and safe antivirals with a novel mechanism of action. Maturation inhibitors (MIs) represent one such new class of HIV therapies. MIs inhibit a late step in the HIV-1 Gag...

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PMID: 26713265
DOI: 10.1016/j.apsb.2015.05.004

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