Article
HIV-1 capsid protein and cyclophilin a as new targets for anti-AIDS therapeutic agents.
Infectious disorders drug targets - 1 Sept 2007
Li Jiebo, Tang Shixing, Hewlett Indira, Yang Ming
Abstract excerpt
The emergence of drug resistant mutations in current anti-HIV-1 drug regimens is an important determinant of the eventual drug failure. New drug development strategies that focus on either new targets or novel compounds are therefore critical for future effective viral suppression in HIV-1 infected individuals. Particularly, virus assembly and disassembly are attractive candidate processes for antiviral...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Anti-HIV Agents
- Capsid Proteins
- Cyclophilin A
- Drug Delivery Systems
- Drug Design
- Drug Resistance, Viral
- HIV-1
- Humans
- Mutation