Article

Lenacapavir binding to immature Gag triggers the emergence of giant HIV-1 virions

2025-07-16

Abstract excerpt

Lenacapavir (LEN), a potent capsid inhibitor, suppresses reverse transcription and nuclear import by disrupting capsid core formation in human immunodeficiency virus type 1 (HIV-1). However, its effect on the late-stage viral assembly remains unclear. Although p24 ELISA suggested that LEN inhibited HIV-1, both RT-dPCR and Vpr-HiBiT assays indicated no reduction in the viral output. This discrepancy was attributed...

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Literature Corpus work: 06efb73b-0981-5bbc-8716-5195ad156612
DOI: 10.1101/2025.07.16.665102

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