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HIV-1 Capsid Inhibitors as Antiretroviral Agents

4 Mar 2016

Abstract excerpt

BACKGROUND: The infectious human immunodeficiency virus (HIV) particle is characterized by a conical capsid that encloses the viral RNA genome. The capsid is essential for HIV-1 replication and plays crucial roles in both early and late stages of the viral life cycle. Early on, upon fusion of the viral and cellular membranes, the viral capsid is released into the host cell cytoplasm and dissociates in a process...

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PMID: 26957201
DOI: 10.2174/1570162x14999160224103555

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