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Article

Maturation inhibitors facilitate virus assembly and release of HIV-1 capsid P224 mutant.

Virology - 1 Aug 2018

Timilsina Uddhav, Ghimire Dibya, Adhikari Laxmi Prasad, Bhattarai Abhi, Mishra Nawneet, Rai Madhu, Dubey Ravi Chandra, Gaur Ritu

Abstract excerpt

HIV-1 Maturation inhibitors (MIs) bind to the C-terminal domain of capsid protein (CA-CTD) and spacer peptide 1 (SP1) in HIV-1 Gag and inhibit the CA-SP1 cleavage by stabilizing the immature Gag. The β-turn motif, GVGGP in the HIV CA-CTD (residues 220-224) is one of the key determinants of HIV Gag assembly. In the present study, we mutated each residue of HIV-1 β-turn motif to alanine and observed complete...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsid Proteins

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Genes, gag

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Source

Identifiers

PMID: 29879541
DOI: 10.1016/j.virol.2018.05.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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