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Interactions of HIV-1 Capsid with Host Factors and Their Implications for Developing Novel Therapeutics

5 Mar 2021

Abstract excerpt

The Human Immunodeficiency Virus type 1 (HIV-1) virion contains a conical shell, termed capsid, encasing the viral RNA genome. After cellular entry of the virion, the capsid is released and ensures the protection and delivery of the HIV-1 genome to the host nucleus for integration. The capsid relies on many virus-host factor interactions which are regulated spatiotemporally throughout the course of infection. In...

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PMID: 33807824
DOI: 10.3390/v13030417

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