Article

Structural and Mechanistic Bases for Resistance of the M66I Capsid Variant to Lenacapavir

2024-11-25

Abstract excerpt

<h4>ABSTRACT</h4> Lenacapavir (LEN) is the first in class viral capsid protein (CA) targeting antiretroviral for treating multi-drug-resistant HIV-1 infection. Clinical trials and cell culture experiments have identified resistance associated mutations (RAMs) in the vicinity of the hydrophobic CA pocket targeted by LEN. The M66I substitution conferred by far the highest level of resistance to the inhibitor compar...

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Literature Corpus work: ddb2f557-71d1-55b3-8468-d1012ba8f39a
DOI: 10.1101/2024.11.25.625199

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