Article

Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation decomposes the viral core

2025-04-19

Abstract excerpt

Drugs that covalently bind to their target molecules form strong and irreversible interactions with each other. Covalent inhibitors have recently attracted attention because of their enhanced structural selectivity within the target cavity, which results in prolonged interactions, even at low doses. Here, we report that ACAi-001 is a human immunodeficiency virus (HIV)-1 capsid (CA)-targeting compound with covalent...

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Literature Corpus work: 162a7d3e-c24e-527a-ab52-27ada728763c
DOI: 10.1101/2025.04.19.649630

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