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Article

Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling.

Nature communications - 26 Nov 2019

Kopec Wojciech, Rothberg Brad S, de Groot Bert L

Abstract excerpt

Potassium channels are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control channel opening, closing, and inactivation. However, the molecular mechanism of how these gates regulate K+ion flow through the channel remains poorly understood. An activation process, occurring at the selectivity filter, has been recently proposed for several potassium...

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Identifiers

PMID: 31772184
DOI: 10.1038/s41467-019-13227-w
PMCID: PMC6879586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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