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Article

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.

Nature communications - 30 Aug 2024

Neelsen Lea C, Riel Elena B, Rinné Susanne, Schmid Freya-Rebecca, Jürs Björn C, Bedoya Mauricio, Langer Jan P, Eymsh Bisher, Kiper Aytug K, Cordeiro Sönke, Decher Niels, Baukrowitz Thomas, Schewe Marcus

Abstract excerpt

Two-pore domain K+ (K2P) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower gate at the cytoplasmic pore entrance. Here, we report functional evidence of such a lower gate in the K2P channel K2P17.1 (TALK-2, TASK-4). We identified compounds (drugs and lipids) and mutations that opened the...

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Identifiers

PMID: 39215031
DOI: 10.1038/s41467-024-51812-w
PMCID: PMC11364775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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