Article

Evaluating Inositol phospholipid interactions with Inward Rectifier Potassium Channels and characterising their role in Disease

2020-09-03

Abstract excerpt

Membrane proteins are frequently modulated by specific protein-lipid interactions. The activation of human inward rectifying potassium (hKir) channels by phosphoinositides (PI) has been well characterised. Here, we apply a coarse-grained molecular dynamics free-energy perturbation (CG-FEP) protocol to capture the energetics of binding of PI lipids to hKir channels. By using either a single- or multi-step approach,...

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Literature Corpus work: 5be2d3ed-c877-5bcb-990d-b2d94a0b5251
DOI: 10.1101/2020.09.03.281378

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