Article

Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures

2022-09-03

Abstract excerpt

Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient relationships of metastases that evade treatment, we performed genomewide copy number profiling and bespoke approaches targeting the androgen receptor (AR) on 142 metastatic regions from 10 organs harvested post-mortem from nine men who died from prostate cancer. We ide...

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Literature Corpus work: 646ca5df-623b-5eb6-b49a-d4f4ff5caeb5
DOI: 10.1101/2022.09.01.506183

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